Jana Reddy political career initiated by joining the Telugu Desam Party founded by Nandamuri Taraka Rama Rao, and was first elected to the State Legislature from the Chalakurthi constituency of the Nalgonda district in 1983. He was re-elected for 6 terms to the Assembly from the Chalakurthi constituency, and went on to hold portfolios such as Agriculture, Co-operative, Marketing, Forest, Animal Husbandry, Fisheries, Weights & Measures, C.A.D.,Transport, Roads & Buildings,Housing Panchayath Raj, Rural water scheme and Sanitation in the Government of Andhra Pradesh. He is the longest serving cabinet minister in govt of Telangana breaking the record of Sri Kasu Bramanadha Reddy former chief minister of A.P.
Jana Reddy resigned from the Telugu Desam Party after differing with N.T.Rama Rao on expelling 30 cabinet ministers in 1988 and founded a political party - Telugumahanadu which eventually merged with Congress on call given by then AICC president Shri Late Rajiv Gandhi ji. He played an active role in reviving the Congress Party specifically in the Telangana Region to fight the then ruling Telugu Desam Party which lost the elections in 2004 to the Congress Party. Jana Reddy was sworn in as the Minister for Home Affairs in the 2004 AP Cabinet for his progressive contribution to the Congress Party.
Known for his vast experience spanning 30 years in AP state politics, administration and impeccable track record Jana Reddy, served as the Minister for Panchayati Raj & RWS - Andhra Pradesh, apart from being active in the Telangana movement and has led various delegations to All India Congress Committee (AICC) representing the Telangana Statehood issue. Now he is opposition leader in Telangana state assembly from congress party.