Padma Devender Reddy joined right at the inception in April 2001. She was elected as ZPTC Member form Ramayampet to Medak Zilla Parishad in 2001 local body elections and served as floor leader of the TRS party. After the formation of TRS party, She won with a huge margin of 12,000 votes at the time.
She was an MLA from 2004 - 2009 from the same constituency. She lost the election in 2009 general elections.
She was suspended from the TRS party in 2009 and contested as a rebel. She joined TRS again in 2010. She won again as MLA in 2014 General elections from Medak assembly constituency defeating actress, Vijayashanti.
On 12 June 2014, Padma Devender Reddy was elected unanimously as Deputy Speaker of the Telangana State Legislative Assembly, becoming the First Deputy Speaker in the newly created state of Telangana.